Tetanus Gamma Dosage/Direction for Use

Prophylaxis of tetanus prone wounds: 250 IU, unless the risk is thought to be extremely high.
The dose may be increased to 500 IU in the case of: infected wounds, where surgically appropriate treatment cannot be achieved within 24 hours; deep or contaminated wounds with tissue damage and reduced oxygen supply, as well as foreign body injury (e.g. bites, stings or shots).
Therapy of clinically manifest tetanus: Several studies suggest a value of human tetanus immunoglobulin in the treatment of clinically manifest tetanus equal to single doses of 3000 to 6000 IU in combination with other appropriate clinical procedures.
Paediatric population: The posology in children and adolescents (0-18 years) is not different to that of adults.
Method of administration: Human tetanus immunoglobulin should be administered via the intramuscular route.
If a large volume (>2 ml for children or >5 ml for adults) is required, it is recommended to administer divided doses at different sites.
When simultaneous vaccination is necessary, the immunoglobulin and the vaccine should be administered at two different sites.
For prophylaxis, if intramuscular administration is contra-indicated (bleeding disorders), the injection can be administered subcutaneously. However, it should be noted that there are no clinical efficacy data to support administration by the subcutaneous route.
For acute therapy, if intramuscular administration is not clinically appropriate, an alternative intravenous product may be used if available.